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Target
Renin
Ligand
BDBM50016021
Substrate
n/a
Meas. Tech.
ChEBML_192730
IC50
3800±n/a nM
Citation
 Kaltenbronn, JS; Hudspeth, JP; Lunney, EA; Michniewicz, BM; Nicolaides, ED; Repine, JT; RoarK, WH; Stier, MA; Tinney, FJ; Woo, PK Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites. J Med Chem 33:838-45 (1990) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50016021
Synonyms:
CHEMBL354767 | {1-Benzyl-2-[1-[1-benzyl-3-(1-benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylamino]-ethyl}-carbamic acid tert-butyl ester : (0.2 chloroform)
Type:
Small organic molecule
Emp. Form.:
C44H59N7O6
Mol. Mass.:
781.9826
SMILES:
CC(C)C[C@H](NC(=O)C[C@@H](O)C(Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCc1ccccc1
Structure:
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