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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM39862
Substrate
n/a
Meas. Tech.
ChEMBL_1726368 (CHEMBL4141646)
IC50
20±n/a nM
Citation
 Saddique, FA; Zaib, S; Jalil, S; Aslam, S; Ahmad, M; Sultan, S; Naz, H; Iqbal, M; Iqbal, J Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides. Eur J Med Chem 143:1373-1386 (2018) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM39862
Synonyms:
Deprenyl | METHYL-(1-METHYL-2-PHENYL-ETHYL)-PROP-2-YNYL-AMINE HYDROCHLORIDE | MLS000069378 | N-methyl-1-phenyl-N-prop-2-ynyl-2-propanamine;hydrochloride | N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine;hydrochloride | N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine;hydrochloride | SMR000058408 | Selegiline | cid_92913 | methyl-(1-methyl-2-phenyl-ethyl)-propargyl-amine;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C13H17N
Mol. Mass.:
187.2808
SMILES:
CC(Cc1ccccc1)N(C)CC#C
Structure:
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