Reaction Details
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Lysophosphatidic acid receptor 1
Ligand
BDBM50285789
Substrate
n/a
Meas. Tech.
ChEMBL_1728729 (CHEMBL4144007)
IC50
13±n/a nM
Citation
Terakado, M; Suzuki, H; Hashimura, K; Tanaka, M; Ueda, H; Hirai, K; Asada, M; Ikura, M; Matsunaga, N; Saga, H; Shinozaki, K; Karakawa, N; Takada, Y; Minami, M; Egashira, H; Sugiura, Y; Yamada, M; Nakade, S; Takaoka, Y Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett 8:1281-1286 (2017) [PubMed] Article More Info.:
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
Inhibitor
Name:
BDBM50285789
Synonyms:
CHEMBL4169559
Type:
Small organic molecule
Emp. Form.:
C27H33NO5
Mol. Mass.:
451.5546
SMILES:
COc1cc(cc(OC)c1C)[C@@H](O)[C@@H](CCCc1ccccc1)Cn1ccc(CC(O)=O)c1 |r|
Structure:
