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Target
Mu-type opioid receptor
Ligand
BDBM86417
Substrate
n/a
Meas. Tech.
ChEMBL_146539 (CHEMBL873301)
Ki
9290±n/a nM
Citation
 Schiller, PW; Nguyen, TM; Chung, NN; Lemieux, C Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity. J Med Chem 32:698-703 (1989) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM86417
Synonyms:
5-amino-2-{1-[1-[1-amino-2-(4-hydroxyphenyl)ethylcarboxamido]-4-amino(imino)methylamino-(1R)-butylcarboxamido]-2-phenylethylcarboxamido}pentanamide | CHEMBL2371282 | Tyr-d-Arg-Phe-Orn-NH2
Type:
Small organic molecule
Emp. Form.:
C29H43N9O5
Mol. Mass.:
597.709
SMILES:
[#7]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](-[#7])=O
Structure:
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