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Target
Delta-type opioid receptor
Ligand
BDBM50016867
Substrate
n/a
Meas. Tech.
ChEBML_146905
Ki
19200±n/a nM
Citation
 Schiller, PW; Nguyen, TM; Chung, NN; Lemieux, C Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity. J Med Chem 32:698-703 (1989) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50016867
Synonyms:
(S)-6-Amino-2-((S)-2-{(R)-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-phenyl-propionylamino)-hexanoic acid amide | 6-amino-2-[1-[1-[1-amino-2-(4-hydroxyphenyl)-(1S)-ethylcarboxamido]-4-amino(imino)methylamino-(1R)-butylcarboxamido]-2-phenyl-(1S)-ethylcarboxamido]-(2S)-hexanamide | CHEMBL60444
Type:
Small organic molecule
Emp. Form.:
C30H45N9O5
Mol. Mass.:
611.7356
SMILES:
NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O
Structure:
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