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Target
Mu-type opioid receptor
Ligand
BDBM50016869
Substrate
n/a
Meas. Tech.
ChEMBL_146539 (CHEMBL873301)
Ki
2220±n/a nM
Citation
 Schiller, PW; Nguyen, TM; Chung, NN; Lemieux, C Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity. J Med Chem 32:698-703 (1989) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50016869
Synonyms:
12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2-benzyl-3,7,13-trioxo-1,4,8triaza-cyclotridecane-5-carboxylic acid amide | CHEMBL2371283
Type:
Small organic molecule
Emp. Form.:
C26H32N6O6
Mol. Mass.:
524.5689
SMILES:
N[C@H](C(=O)N[C@H]1CCCNC(=O)C[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O)c1ccc(O)cc1
Structure:
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