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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM25796
Substrate
n/a
Meas. Tech.
ChEMBL_1732058 (CHEMBL4147594)
IC50
160±n/a nM
Citation
 Chollet, A; Maveyraud, L; Lherbet, C; Bernardes-Génisson, V An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors. Eur J Med Chem 146:318-343 (2018) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM25796
Synonyms:
5-{[4-(9H-fluoren-9-yl)piperazin-1-yl]carbonyl}-1H-indole | piperazine, p3
Type:
Small organic molecule
Emp. Form.:
C26H23N3O
Mol. Mass.:
393.4803
SMILES:
O=C(N1CCN(CC1)C1c2ccccc2-c2ccccc12)c1ccc2[nH]ccc2c1
Structure:
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