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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50376902
Substrate
n/a
Meas. Tech.
ChEMBL_1732226 (CHEMBL4147762)
IC50
1110±n/a nM
Citation
 Wan, Y; Dai, N; Tang, Z; Fang, H Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. Eur J Med Chem 146:471-482 (2018) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50376902
Synonyms:
CHEMBL408194
Type:
Small organic molecule
Emp. Form.:
C20H19N3O
Mol. Mass.:
317.3844
SMILES:
COC1=CC(=N\C1=C/c1[nH]c(C)cc1C)c1cc2ccccc2[nH]1 |c:4,t:2|
Structure:
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