Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50145685
Substrate
n/a
Meas. Tech.
ChEMBL_1732906 (CHEMBL4148442)
IC50
0.910000±n/a nM
Citation
 Shah, HR; Savjani, JK Recent updates for designing CCR5 antagonists as anti-retroviral agents. Eur J Med Chem 147:115-129 (2018) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | CC-CKR-5 | CCR-5 | CCR5_MOUSE | CD_antigen=CD195 | Ccr5 | Cmkbr5 | MIP-1 alpha receptor
Type:
PROTEIN
Mol. Mass.:
40803.93
Organism:
Mus musculus
Description:
ChEMBL_49996
Residue:
354
Sequence:
MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEVSTGL
  
Inhibitor
Name:
BDBM50145685
Synonyms:
(4,6-Dimethyl-pyrimidin-5-yl)-(4-{(S)-4-[(R)-2-methoxy-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidin-1-yl)-methanone | CHEMBL82301
Type:
Small organic molecule
Emp. Form.:
C28H38F3N5O2
Mol. Mass.:
533.6288
SMILES:
COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: