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Target
Cyclin-dependent kinase 8
Ligand
BDBM50352632
Substrate
n/a
Meas. Tech.
ChEMBL_1734990 (CHEMBL4150526)
IC50
15±n/a nM
Citation
 Hatcher, JM; Wang, ES; Johannessen, L; Kwiatkowski, N; Sim, T; Gray, NS Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett 9:540-545 (2018) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 8
Synonyms:
CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35
Type:
Serine/threonine-protein kinase
Mol. Mass.:
53300.21
Organism:
Homo sapiens (Human)
Description:
P49336
Residue:
464
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
  
Inhibitor
Name:
BDBM50352632
Synonyms:
CHEMBL4167143
Type:
Small organic molecule
Emp. Form.:
C30H36N2O3
Mol. Mass.:
472.6184
SMILES:
CN(C)[C@H]1C[C@@]23CC[C@]4(O2)C2CC[C@H](c5ccc6ccncc6c5)[C@@]2(C)CC=C4C=C3[C@@H](O)[C@@H]1O |r,c:31,34|
Structure:
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