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Target
Neuraminidase
Ligand
BDBM50365364
Substrate
n/a
Meas. Tech.
ChEMBL_1735172 (CHEMBL4150708)
Ki
20±n/a nM
Citation
 Zhang, J; Poongavanam, V; Kang, D; Bertagnin, C; Lu, H; Kong, X; Ju, H; Lu, X; Gao, P; Tian, Y; Jia, H; Desta, S; Ding, X; Sun, L; Fang, Z; Huang, B; Liang, X; Jia, R; Ma, X; Xu, W; Murugan, NA; Loregian, A; Huang, B; Zhan, P; Liu, X Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant. J Med Chem 61:6379-6397 (2018) [PubMed]  Article 
Target
Name:
Neuraminidase
Synonyms:
NA | NRAM_I71A1
Type:
PROTEIN
Mol. Mass.:
52105.18
Organism:
Influenza A virus (strain A/Memphis/1/1971 H3N2)
Description:
ChEMBL_578382
Residue:
469
Sequence:
MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIERNITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCVTGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCICRDNWKGSNRPVVDINVKDYSIDSRYVCSGLVGDTPRNNDRSSNSNCRNPNNDKGNHGVKGWAFDDGNDVWMGRTISKDSRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINRCFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
  
Inhibitor
Name:
BDBM50365364
Synonyms:
CHEMBL4161008
Type:
Small organic molecule
Emp. Form.:
C19H31N5O5
Mol. Mass.:
409.4799
SMILES:
CCC(CC)O[C@@H]1C=C([C@@H]([C@H](N)[C@H]1NC(C)=O)n1cc(nn1)C(O)CC)C(O)=O |r,c:7|
Structure:
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