Reaction Details Report a problem with these data
Target
Excitatory amino acid transporter 4
Ligand
BDBM50366614
Substrate
n/a
Meas. Tech.
ChEMBL_1735433 (CHEMBL4150969)
IC50
140±n/a nM
Citation
 Fu, H; Zhang, J; Tepper, PG; Bunch, L; Jensen, AA; Poelarends, GJ Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. J Med Chem 61:7741-7753 (2018) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 4
Synonyms:
EAA4_RAT | Eaat4 | Excitatory amino acid transporter 4 | High-affinity neuronal glutamate transporter | Slc1a6 | Sodium-dependent glutamate/aspartate transporter | Solute carrier family 1 member 6
Type:
PROTEIN
Mol. Mass.:
60724.56
Organism:
Rattus norvegicus
Description:
ChEMBL_100180
Residue:
561
Sequence:
MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTREHVRRFLRRNAFILLTVSAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRALGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM
  
Inhibitor
Name:
BDBM50366614
Synonyms:
CHEMBL4176482
Type:
Small organic molecule
Emp. Form.:
C23H19BrF2N2O5
Mol. Mass.:
521.308
SMILES:
N[C@@H]([C@H](OCc1ccccc1)C(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: