Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50367222
Substrate
n/a
Meas. Tech.
ChEMBL_1735727 (CHEMBL4151263)
EC50
2.3±n/a nM
Citation
 Chen, HY; Plummer, CW; Xiao, D; Chobanian, HR; DeMong, D; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Di Salvo, J; Thomas-Fowlkes, B; Souza, S; Tatosian, DA; Chen, Q; Hafey, MJ; Houle, R; Nolting, AF; Orr, R; Ehrhart, J; Weinglass, AB; Tschirret-Guth, R; Howard, AD; Colletti, SL Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs. ACS Med Chem Lett 9:685-690 (2018) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_RAT | Mc4r
Type:
PROTEIN
Mol. Mass.:
36892.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11005
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
  
Inhibitor
Name:
BDBM50367222
Synonyms:
CHEMBL4162778
Type:
Small organic molecule
Emp. Form.:
C28H27FNNaO4
Mol. Mass.:
483.5065
SMILES:
[Na;v0+].[#6]-[#8]-c1ccc(F)c(c1)-c1ccc(nc1)-[#6]-1-[#6]-[#6]-c2ccc(cc2-[#8]-1)-[#6@@H](-[#6@H](-[#6])-[#6](-[#8-])=O)-[#6]-1-[#6]-[#6]-1 |r|
Structure:
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