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Target
Vesicular acetylcholine transporter
Ligand
BDBM50018096
Substrate
n/a
Meas. Tech.
ChEBML_27660
IC50
500±n/a nM
Citation
 Rogers, GA; Parsons, SM; Anderson, DC; Nilsson, LM; Bahr, BA; Kornreich, WD; Kaufman, R; Jacobs, RS; Kirtman, B Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol). J Med Chem 32:1217-30 (1989) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50018096
Synonyms:
4-(4-Chloro-phenyl)-1-(2-hydroxy-cyclohexyl)-piperidin-4-ol | CHEMBL20657
Type:
Small organic molecule
Emp. Form.:
C17H24ClNO2
Mol. Mass.:
309.831
SMILES:
OC1CCCCC1N1CCC(O)(CC1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: