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Target
Vesicular acetylcholine transporter
Ligand
BDBM50018099
Substrate
n/a
Meas. Tech.
ChEBML_27660
IC50
500±n/a nM
Citation
 Rogers, GA; Parsons, SM; Anderson, DC; Nilsson, LM; Bahr, BA; Kornreich, WD; Kaufman, R; Jacobs, RS; Kirtman, B Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol). J Med Chem 32:1217-30 (1989) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50018099
Synonyms:
CHEMBL417277 | N-[7-Hydroxy-6-(4-phenyl-piperidin-1-yl)-5,6,7,8-tetrahydro-naphthalen-1-yl]-succinamic acid
Type:
Small organic molecule
Emp. Form.:
C25H30N2O4
Mol. Mass.:
422.5167
SMILES:
OC1Cc2c(CC1N1CCC(CC1)c1ccccc1)cccc2NC(=O)CCC(O)=O
Structure:
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