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Target
Thromboxane-A synthase
Ligand
BDBM50018179
Substrate
n/a
Meas. Tech.
ChEMBL_210089 (CHEMBL812002)
IC50
13±n/a nM
Citation
 Amemiya, Y; Terada, A; Wachi, K; Miyazawa, H; Hatakeyama, N; Matsuda, K; Oshima, T Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives. J Med Chem 32:1265-72 (1989) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1
Type:
PROTEIN
Mol. Mass.:
59971.80
Organism:
Rattus norvegicus
Description:
ChEMBL_209768
Residue:
533
Sequence:
MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
  
Inhibitor
Name:
BDBM50018179
Synonyms:
2-Imidazol-1-ylmethyl-4,5-dihydro-benzo[b]thiophene-6-carboxylic acid | CHEMBL22542 | Imitrodast
Type:
Small organic molecule
Emp. Form.:
C13H12N2O2S
Mol. Mass.:
260.312
SMILES:
OC(=O)C1=Cc2sc(Cn3ccnc3)cc2CC1 |t:3|
Structure:
Search PDB for entries with ligand similarity: