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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50406882
Substrate
n/a
Meas. Tech.
ChEMBL_1739344 (CHEMBL4155094)
IC50
>10000±n/a nM
Citation
 Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors. Eur J Med Chem 154:101-109 (2018) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty
Type:
PROTEIN
Mol. Mass.:
57124.52
Organism:
Mus musculus
Description:
ChEMBL_1502245
Residue:
483
Sequence:
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT
  
Inhibitor
Name:
BDBM50406882
Synonyms:
CHEMBL4166554
Type:
Small organic molecule
Emp. Form.:
C15H11N3O3
Mol. Mass.:
281.2661
SMILES:
OC(=O)c1nc2ccccc2nc1Nc1ccccc1O
Structure:
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