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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM25013
Substrate
n/a
Meas. Tech.
ChEMBL_1740582 (CHEMBL4156332)
IC50
6970±n/a nM
Citation
 Alt?ntop, MD; Sever, B; Akal?n Çiftçi, G; Turan-Zitouni, G; Kaplanc?kl?, ZA; Özdemir, A Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. Eur J Med Chem 155:905-924 (2018) [PubMed]  Article 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
2.7.11.1 | AKT1_RAT | Akt1 | PKB | PKB alpha | Protein kinase B | Protein kinase B alpha | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase
Type:
PROTEIN
Mol. Mass.:
55728.72
Organism:
Rattus norvegicus
Description:
ChEMBL_102911
Residue:
480
Sequence:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM25013
Synonyms:
4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | GSK-690693 | GSK690693 | US10550114, Compound GSK690693
Type:
Small organic molecule
Emp. Form.:
C21H27N7O3
Mol. Mass.:
425.4842
SMILES:
CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r|
Structure:
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