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Target
Free fatty acid receptor 2
Ligand
BDBM403752
Substrate
n/a
Meas. Tech.
ChEMBL_1742413 (CHEMBL4158163)
Ki
479±n/a nM
Citation
 Hansen, AH; Sergeev, E; Bolognini, D; Sprenger, RR; Ekberg, JH; Ejsing, CS; McKenzie, CJ; Rexen Ulven, E; Milligan, G; Ulven, T Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem 61:9534-9550 (2018) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM403752
Synonyms:
(2S,5R)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid | US10017468, Compound 1 | US10781171, Compound 1 | US11072582, Compound 1
Type:
Small organic molecule
Emp. Form.:
C25H22ClNO4
Mol. Mass.:
435.899
SMILES:
COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Structure:
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