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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50018740
Substrate
n/a
Meas. Tech.
ChEMBL_33103 (CHEMBL645956)
Ki
2818±n/a nM
Citation
 Huff, JR; Baldwin, JJ; deSolms, SJ; Guare, JP; Hunt, CA; Randall, WC; Sanders, WS; Smith, SJ; Vacca, JP; Zrada, MM Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors. J Med Chem 31:641-5 (1988) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51492.08
Organism:
CALF
Description:
adrenergic Alpha1 0 CALF
Residue:
466
Sequence:
MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
  
Inhibitor
Name:
BDBM50018740
Synonyms:
4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinolizin-2-ylamine | CHEMBL160388
Type:
Small organic molecule
Emp. Form.:
C10H15N3S
Mol. Mass.:
209.311
SMILES:
Nc1nc2C3CCCCN3CCc2s1
Structure:
Search PDB for entries with ligand similarity: