Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM50450437
Substrate
n/a
Meas. Tech.
ChEMBL_1742527 (CHEMBL4158277)
EC50
100±n/a nM
Citation
 Hoveyda, HR; Fraser, GL; Zoute, L; Dutheuil, G; Schils, D; Brantis, C; Lapin, A; Parcq, J; Guitard, S; Lenoir, F; Bousmaqui, ME; Rorive, S; Hospied, S; Blanc, S; Bernard, J; Ooms, F; McNelis, JC; Olefsky, JM N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem 26:5169-5180 (2018) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFAR2_MOUSE | Ffar2 | G-protein coupled receptor 43 | Gpr43 | Leukocyte-specific STAT-induced GPCR | Lssig
Type:
PROTEIN
Mol. Mass.:
37133.99
Organism:
Mus musculus
Description:
ChEMBL_109188
Residue:
330
Sequence:
MTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE
  
Inhibitor
Name:
BDBM50450437
Synonyms:
CHEMBL4177037
Type:
Small organic molecule
Emp. Form.:
C28H29N5O3S
Mol. Mass.:
515.627
SMILES:
CC(C)C[C@H](CC(O)=O)C(=O)N(C1CC1)c1nc(cs1)-c1ccccc1-c1ccc(nc1)-n1cccn1 |r|
Structure:
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