Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM50450441
Substrate
n/a
Meas. Tech.
ChEMBL_1742530 (CHEMBL4158280)
Ki
251±n/a nM
Citation
 Hoveyda, HR; Fraser, GL; Zoute, L; Dutheuil, G; Schils, D; Brantis, C; Lapin, A; Parcq, J; Guitard, S; Lenoir, F; Bousmaqui, ME; Rorive, S; Hospied, S; Blanc, S; Bernard, J; Ooms, F; McNelis, JC; Olefsky, JM N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem 26:5169-5180 (2018) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM50450441
Synonyms:
CHEMBL4173387
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2O3S
Mol. Mass.:
406.926
SMILES:
CN(C(=O)[C@H](CC1CCCC1)CC(O)=O)c1nc(cs1)-c1ccccc1Cl |r|
Structure:
Search PDB for entries with ligand similarity: