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Target
Amyloid beta-binding alcohol dehydrogenase
Ligand
BDBM50450824
Substrate
n/a
Meas. Tech.
ChEMBL_1743490 (CHEMBL4178000)
IC50
92±n/a nM
Citation
 Hroch, L; Guest, P; Benek, O; Soukup, O; Janockova, J; Dolezal, R; Kuca, K; Aitken, L; Smith, TK; Gunn-Moore, F; Zala, D; Ramsay, RR; Musilek, K Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment. Bioorg Med Chem 25:1143-1152 (2017) [PubMed]  Article 
Target
Name:
Amyloid beta-binding alcohol dehydrogenase
Synonyms:
Amyloid beta-binding alcohol dehydrogenase (ABAD)
Type:
Enzyme
Mol. Mass.:
938.17
Organism:
Homo sapiens (Human)
Description:
Q2L8D9
Residue:
9
Sequence:
MAAACRSVK
  
Inhibitor
Name:
BDBM50450824
Synonyms:
CHEMBL4203009
Type:
Small organic molecule
Emp. Form.:
C19H21N5OS
Mol. Mass.:
367.468
SMILES:
O=C(C(c1ccccc1)n1cnc2[nH]ncc2c1=S)N1CCCCCC1
Structure:
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