Reaction Details
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5-hydroxytryptamine receptor 2C
Ligand
BDBM50451049
Substrate
n/a
Meas. Tech.
ChEMBL_1744658 (CHEMBL4179168)
Ki
12±n/a nM
Citation
Fiorino, F; Magli, E; K?dzierska, E; Ciano, A; Corvino, A; Severino, B; Perissutti, E; Frecentese, F; Di Vaio, P; Saccone, I; Izzo, AA; Capasso, R; Massarelli, P; Rossi, I; Orzelska-Gòrka, J; Kotli?ska, JH; Santagada, V; Caliendo, G New 5-HT Bioorg Med Chem 25:5820-5837 (2017) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
Type:
Enzyme
Mol. Mass.:
51935.10
Organism:
Rattus norvegicus (Rat)
Description:
P08909
Residue:
460
Sequence:
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
Inhibitor
Name:
BDBM50451049
Synonyms:
CHEMBL4206623
Type:
Small organic molecule
Emp. Form.:
C19H23FN4O
Mol. Mass.:
342.4105
SMILES:
Fc1ccc(cc1)N1CCN(CCCNC(=O)c2ccccn2)CC1
Structure:
