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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50451613
Substrate
n/a
Meas. Tech.
ChEMBL_1745955 (CHEMBL4180465)
EC50
26±n/a nM
Citation
 Cook, J; Zusi, FC; Hill, MD; Fang, H; Pearce, B; Park, H; Gallagher, L; McDonald, IM; Bristow, L; Macor, JE; Olson, RE Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor. Bioorg Med Chem Lett 27:5002-5005 (2017) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50451613
Synonyms:
CHEMBL4211836
Type:
Small organic molecule
Emp. Form.:
C22H23N3O2
Mol. Mass.:
361.4369
SMILES:
COc1ccc(cc1)-c1cccc2n3C[C@@]4(CN5CCC4CC5)Oc3nc12 |r,wU:15.25,THB:23:15:18.19:22.21,(21.29,-19.75,;22.44,-20.88,;22.03,-22.43,;23.18,-23.57,;22.78,-25.13,;21.22,-25.55,;20.07,-24.43,;20.47,-22.87,;20.81,-27.11,;21.91,-28.19,;21.52,-29.67,;20.04,-30.08,;18.95,-29,;17.42,-29.08,;16.23,-30.05,;14.94,-29.22,;15.24,-30.68,;13.81,-30.02,;12.2,-30.71,;11.99,-29.26,;13.54,-28.59,;13.6,-26.87,;14.08,-28.03,;15.33,-27.74,;16.86,-27.65,;18.05,-26.68,;19.33,-27.51,)|
Structure:
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