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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50452630
Substrate
n/a
Meas. Tech.
ChEMBL_1748007 (CHEMBL4182517)
Ki
382000±n/a nM
Citation
 Kozarski, M; Kubacka, D; Wojtczak, BA; Kasprzyk, R; Baranowski, MR; Kowalska, J 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem 26:191-199 (2018) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50452630
Synonyms:
CHEMBL4203412
Type:
Small organic molecule
Emp. Form.:
C13H17N8O7P
Mol. Mass.:
428.2972
SMILES:
C[n+]1cn([C@@H]2O[C@H](Cn3cc(nn3)P(O)([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Structure:
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