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Target
Presenilin-1
Ligand
BDBM50452831
Substrate
n/a
Meas. Tech.
ChEMBL_1748462 (CHEMBL4182972)
IC50
5800±n/a nM
Citation
 Sekioka, R; Honjo, E; Honda, S; Fuji, H; Akashiba, H; Mitani, Y; Yamasaki, S Discovery of novel scaffolds for ?-secretase modulators without an arylimidazole moiety. Bioorg Med Chem 26:435-442 (2018) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50452831
Synonyms:
CHEMBL4207974
Type:
Small organic molecule
Emp. Form.:
C26H35Cl2N3O
Mol. Mass.:
476.482
SMILES:
Cl.Cl.Cc1nc2c(OCc3ccccc3)cccn2c1C1CCN(CC1)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: