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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50165008
Substrate
n/a
Meas. Tech.
ChEMBL_1749029 (CHEMBL4183539)
Ki
3.1±n/a nM
Citation
 Kawamura, S; Ito, Y; Hirokawa, T; Hikiyama, E; Yamada, S; Shuto, S Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand. J Med Chem 61:4020-4029 (2018) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50165008
Synonyms:
(+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol | (+)-Tolterodine | 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol | CHEMBL1382 | TOLTERODINE
Type:
Small organic molecule
Emp. Form.:
C22H31NO
Mol. Mass.:
325.4876
SMILES:
CC(C)N(CC[C@H](c1ccccc1)c1cc(C)ccc1O)C(C)C
Structure:
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