Reaction Details Report a problem with these data
Target
Cryptochrome-2
Ligand
BDBM356663
Substrate
n/a
Meas. Tech.
ChEMBL_1750223 (CHEMBL4184983)
EC50
194±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:293-297 (2018) [PubMed]  Article 
Target
Name:
Cryptochrome-2
Synonyms:
CRY2 | CRY2_HUMAN | Cryptochrome-2 | KIAA0658
Type:
PROTEIN
Mol. Mass.:
66958.43
Organism:
Homo sapiens
Description:
ChEMBL_118347
Residue:
593
Sequence:
MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA
  
Inhibitor
Name:
BDBM356663
Synonyms:
1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypropyl)-3,3- difluoropiperidin-2- one | US10214507, Compound 13 | US10759777, Compound 13
Type:
Small organic molecule
Emp. Form.:
C20H18F4N2O2
Mol. Mass.:
394.3627
SMILES:
OC(CN1CCCC(F)(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Structure:
Search PDB for entries with ligand similarity: