Reaction Details
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Cryptochrome-2
Ligand
BDBM50453630
Substrate
n/a
Meas. Tech.
ChEMBL_1750223 (CHEMBL4184983)
EC50
833±n/a nM
TBA Bioorg Med Chem Lett 28:293-297 (2018) More Info.:
Target
Name:
Cryptochrome-2
Synonyms:
CRY2 | CRY2_HUMAN | Cryptochrome-2 | KIAA0658
Type:
PROTEIN
Mol. Mass.:
66958.43
Organism:
Homo sapiens
Description:
ChEMBL_118347
Residue:
593
Sequence:
MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA
Inhibitor
Name:
BDBM50453630
Synonyms:
CHEMBL4210300
Type:
Small organic molecule
Emp. Form.:
C20H21F2N3O2
Mol. Mass.:
373.3964
SMILES:
CC1CNC(=O)N(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1
Structure:
