Reaction Details
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Cryptochrome-2
Ligand
BDBM50453644
Substrate
n/a
Meas. Tech.
ChEMBL_1750223 (CHEMBL4184983)
EC50
1186±n/a nM
TBA Bioorg Med Chem Lett 28:293-297 (2018) More Info.:
Target
Name:
Cryptochrome-2
Synonyms:
CRY2 | CRY2_HUMAN | Cryptochrome-2 | KIAA0658
Type:
PROTEIN
Mol. Mass.:
66958.43
Organism:
Homo sapiens
Description:
ChEMBL_118347
Residue:
593
Sequence:
MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA
Inhibitor
Name:
BDBM50453644
Synonyms:
CHEMBL4215504
Type:
Small organic molecule
Emp. Form.:
C19H19F2N3O2
Mol. Mass.:
359.3699
SMILES:
CC1CNC(=O)N1CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Structure:
