Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-1
Ligand
BDBM50453645
Substrate
n/a
Meas. Tech.
ChEMBL_1750251 (CHEMBL4185011)
Ki
6530±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:278-283 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50453645
Synonyms:
CHEMBL4212662
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3S
Mol. Mass.:
326.37
SMILES:
COc1ccc(\C=C2/NC(=S)N(C2=O)c2ccccc2)cc1O
Structure:
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