Reaction Details Report a problem with these data
Target
Ubiquitin-like modifier-activating enzyme 6
Ligand
BDBM50285607
Substrate
n/a
Meas. Tech.
ChEMBL_1750758 (CHEMBL4185518)
IC50
>1000±n/a nM
Citation
 Buuh, ZY; Lyu, Z; Wang, RE Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem 61:3239-3252 (2018) [PubMed]  Article 
Target
Name:
Ubiquitin-like modifier-activating enzyme 6
Synonyms:
E1-L2 | MOP-4 | MOP4 | Monocyte protein 4 | UBA6 | UBA6_HUMAN | UBE1L2 | Ubiquitin-activating enzyme 6 | Ubiquitin-activating enzyme E1-like protein 2
Type:
PROTEIN
Mol. Mass.:
117960.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939704
Residue:
1052
Sequence:
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
  
Inhibitor
Name:
BDBM50285607
Synonyms:
MLN-4924 | MLN-4924003 | Pevonedistat
Type:
Small organic molecule
Emp. Form.:
C21H25N5O4S
Mol. Mass.:
443.519
SMILES:
[H][C@]1(O)C[C@@]([H])(C[C@@]1([H])COS(N)(=O)=O)n1ccc2c(N[C@@]3([H])CCc4ccccc34)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: