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Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Ligand
BDBM50453860
Substrate
n/a
Meas. Tech.
ChEMBL_1751398 (CHEMBL4186158)
IC50
900±n/a nM
Citation
 Fontanillo, M; Köhn, M Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A. Bioorg Med Chem 26:1118-1126 (2018) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms:
PP2AA_BOVIN | PPP2CA | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
PROTEIN
Mol. Mass.:
35586.74
Organism:
Bos taurus
Description:
ChEMBL_161787
Residue:
309
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
  
Inhibitor
Name:
BDBM50453860
Synonyms:
CHEMBL4210922
Type:
Small organic molecule
Emp. Form.:
C35H51N7O11
Mol. Mass.:
745.8197
SMILES:
CC(C)C[C@@H]1NC(=O)[C@@H](C)NC(=O)CN(C)C(=O)CC[C@@H](NC(=O)[C@@H](C)[C@H](C)NC(=O)[C@H](Cc2ccccc2)NC(=O)C[C@@H](NC1=O)C(O)=O)C(O)=O |r|
Structure:
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