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Target
Tumor necrosis factor
Ligand
BDBM50454023
Substrate
n/a
Meas. Tech.
ChEMBL_1751739 (CHEMBL4186499)
IC50
16500±n/a nM
Citation
 Pandit, SS; Kulkarni, MR; Pandit, YB; Lad, NP; Khedkar, VM Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-? production. Bioorg Med Chem Lett 28:24-30 (2018) [PubMed]  Article 
Target
Name:
Tumor necrosis factor
Synonyms:
C-domain 1 | C-domain 2 | Cachectin | ICD1 | ICD2 | Intracellular domain 1 | Intracellular domain 2 | N-terminal fragment | NTF | TNF-a | TNF-alpha | TNFA_MOUSE | Tnf | Tnfa | Tnfsf2 | Tumor necrosis factor | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form
Type:
PROTEIN
Mol. Mass.:
25889.86
Organism:
Mus musculus
Description:
ChEMBL_10774
Residue:
235
Sequence:
MSTESMIRDVELAEEALPQKMGGFQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPQRDEKFPNGLPLISSMAQTLTLRSSSQNSSDKPVAHVVANHQVEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDTPEGAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL
  
Inhibitor
Name:
BDBM50454023
Synonyms:
CHEMBL4215786
Type:
Small organic molecule
Emp. Form.:
C27H23ClN2O6
Mol. Mass.:
506.934
SMILES:
CCCCn1cnc(CC(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)c1Cl
Structure:
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