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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50454067
Substrate
n/a
Meas. Tech.
ChEMBL_1751766 (CHEMBL4186526)
EC50
>10000±n/a nM
Citation
 Kinoshita, A; Higashino, M; Yoshida, K; Aratani, Y; Kakuuchi, A; Hanada, K; Takeda, H; Naganawa, A; Matsuya, H; Ohmoto, K Synthesis and evaluation of a potent, well-balanced EP Bioorg Med Chem 26:200-214 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50454067
Synonyms:
CHEMBL4211120
Type:
Small organic molecule
Emp. Form.:
C22H33NO4S2
Mol. Mass.:
439.632
SMILES:
CC(C)(C)CC[C@](C)(O)C\C=C\[C@H]1CCC(=O)[C@@H]1CCSc1nc(cs1)C(O)=O |r|
Structure:
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