Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50019393
Substrate
n/a
Meas. Tech.
ChEMBL_60523 (CHEMBL674934)
EC50
20000±n/a nM
Citation
 Weinstock, J; Gaitanopoulos, DE; Stringer, OD; Franz, RG; Hieble, JP; Kinter, LB; Mann, WA; Flaim, KE; Gessner, G Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines. J Med Chem 30:1166-76 (1987) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50019393
Synonyms:
4-(2-Dipropylamino-ethyl)-7-hydroxy-1,3-dihydro-indol-2-one | 7-Hydroxy Ropinirole | CHEMBL587
Type:
Small organic molecule
Emp. Form.:
C16H24N2O2
Mol. Mass.:
276.374
SMILES:
CCCN(CCC)CCc1ccc(O)c2NC(=O)Cc12
Structure:
Search PDB for entries with ligand similarity: