Reaction Details Report a problem with these data
Target
Regulator of G-protein signaling 17
Ligand
BDBM50071058
Substrate
n/a
Meas. Tech.
ChEMBL_1756639 (CHEMBL4191647)
IC50
6000±n/a nM
Citation
 Bodle, CR; Mackie, DI; Hayes, MP; Schamp, JH; Miller, MR; Henry, MD; Doorn, JA; Houtman, JCD; James, MA; Roman, DL Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. J Nat Prod 80:1992-2000 (2017) [PubMed]  Article 
Target
Name:
Regulator of G-protein signaling 17
Synonyms:
RGS17 | RGS17_HUMAN | RGSZ2
Type:
PROTEIN
Mol. Mass.:
24356.71
Organism:
Homo sapiens
Description:
ChEMBL_118219
Residue:
210
Sequence:
MRKRQQSQNEGTPAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGENAGRPTHTTKMESIQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSFVESTAGSSSES
  
Inhibitor
Name:
BDBM50071058
Synonyms:
(2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid | CELASTROL | CHEMBL301982 | cid_4274774
Type:
Small organic molecule
Emp. Form.:
C29H38O4
Mol. Mass.:
450.6096
SMILES:
C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17|
Structure:
Search PDB for entries with ligand similarity: