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Target
Potassium voltage-gated channel subfamily A member 4
Ligand
BDBM50456969
Substrate
n/a
Meas. Tech.
ChEMBL_1758562 (CHEMBL4193570)
IC50
15000±n/a nM
Citation
 Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem 139:232-241 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 4
Synonyms:
KCNA4 | KCNA4L | KCNA4_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.4
Type:
PROTEIN
Mol. Mass.:
73234.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_471773
Residue:
653
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
  
Inhibitor
Name:
BDBM50456969
Synonyms:
CHEMBL4202870
Type:
Small organic molecule
Emp. Form.:
C12H14ClN5O
Mol. Mass.:
279.725
SMILES:
Cc1[nH]c(cc1Cl)C(=O)NC\C=C\c1c[nH]c(N)n1
Structure:
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