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Target
Potassium voltage-gated channel subfamily A member 4
Ligand
BDBM50456969
Substrate
n/a
Meas. Tech.
ChEMBL_1758566 (CHEMBL4193574)
IC50
730±n/a nM
Citation
 Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem 139:232-241 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 4
Synonyms:
KCNA4_RAT | Kcna4 | Potassium voltage-gated channel subfamily A member 4 | RCK4 | RHK1 | RK3 | Voltage-gated potassium channel subunit Kv1.4
Type:
PROTEIN
Mol. Mass.:
73364.40
Organism:
Rattus norvegicus
Description:
ChEMBL_101243
Residue:
655
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTGGSGGGPHHHHQTRGAYSSHDPQGSRGSREEEATRTEKKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETDKNNCSNAKAVETDV
  
Inhibitor
Name:
BDBM50456969
Synonyms:
CHEMBL4202870
Type:
Small organic molecule
Emp. Form.:
C12H14ClN5O
Mol. Mass.:
279.725
SMILES:
Cc1[nH]c(cc1Cl)C(=O)NC\C=C\c1c[nH]c(N)n1
Structure:
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