Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 4
Ligand
BDBM50220547
Substrate
n/a
Meas. Tech.
ChEMBL_1758566 (CHEMBL4193574)
IC50
5700±n/a nM
Citation
 Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem 139:232-241 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 4
Synonyms:
KCNA4_RAT | Kcna4 | Potassium voltage-gated channel subfamily A member 4 | RCK4 | RHK1 | RK3 | Voltage-gated potassium channel subunit Kv1.4
Type:
PROTEIN
Mol. Mass.:
73364.40
Organism:
Rattus norvegicus
Description:
ChEMBL_101243
Residue:
655
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTGGSGGGPHHHHQTRGAYSSHDPQGSRGSREEEATRTEKKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETDKNNCSNAKAVETDV
  
Inhibitor
Name:
BDBM50220547
Synonyms:
4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-amino-1H-imidazol-4-yl)-allyl]-amide | 4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-amino-3H-imidazol-4-yl)-allyl]-amide | CHEMBL397591 | oroidin | oroidin base
Type:
Small organic molecule
Emp. Form.:
C11H11Br2N5O
Mol. Mass.:
389.046
SMILES:
Nc1ncc(C=CCNC(=O)c2cc(Br)c(Br)[nH]2)[nH]1 |w:6.6|
Structure:
Search PDB for entries with ligand similarity: