Reaction Details Report a problem with these data
Target
Mediator of RNA polymerase II transcription subunit 15
Ligand
BDBM50457392
Substrate
n/a
Meas. Tech.
ChEMBL_1759533 (CHEMBL4194541)
Kd
320±n/a nM
Citation
 Liu, N; Tu, J; Dong, G; Wang, Y; Sheng, C Emerging New Targets for the Treatment of Resistant Fungal Infections. J Med Chem 61:5484-5511 (2018) [PubMed]  Article 
Target
Name:
Mediator of RNA polymerase II transcription subunit 15
Synonyms:
GAL11 | MED15 | MED15 | MED15_CANGA | Mediator complex subunit 15 | Mediator of RNA polymerase II transcription subunit 15 | Transcription regulatory protein GAL11
Type:
PROTEIN
Mol. Mass.:
121201.67
Organism:
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /NRRL Y-65) (Yeast) (Torulopsis glabrata)
Description:
ChEMBL_117853
Residue:
1095
Sequence:
MSSKETIPMHQRSQNVAELLTVLMDINKINGGDSTTAEKMKVHAKSFEAALFEKSSSKEEYQKTMKSKIDAMRSTRDKRKRESVGSASMMANLGQDGTNNNNNNNNNNNNNLNMAASFMGGDMFGRNQSPAQNSNANTNLNTNVGPGVNGPNGNDGTANPQMFMNQQAQARQQAAARQLKNRQMGGSSAQQQQLTQQQQQLLNQMRVAPIPKELLQRIPNLPPGVTTWEQVTALAQQNRLSAQDMSIAKDIYKIHQQYLIKAKLQQQQQRQQQQRQQGNPDVNNNMAGSNNNNNNNLPMAQQQMQQRQQQQQQSQQQQNRNPNQRHNVLSQINQMFTADEQRALLQEAMEACKNFQKTHFGGQMSDANKQAFIKKFINSKALKKLEAMRMAQGGNNNANLNKGQADMLQRQQANMQMNQQQQRAAQNQRRGPVMNDAVSQGYNNQMNSAADSTMNNSNQPMNIGNNGVNMIPNQSQQQQQTNRPKEQTPQQPQQRIQSNRSVPMLNPTPEDVEVVRRISAEAAKTQLRLTDLTNSLTPQERDEIKKRLQKNQQLFAQVSSYAPQVYLFTKSESFLKEVLQLRIFIKEILEKCSKGIYVVKLDTVDKLVIKYQKYWESMKIQLLRRQQLLQQQQQQQQQGMDPNRAQNSQQQQQQNQANMQQARNRKPTKNQTTPAIAASVAMNMNDKGASMSPALQKAGSAVPNFAQQMSPNMTPGTIPPTNVLSPHSQSHIPMVSPTMAKAASAAALKNDTASSSRRGSTKPRGKSTAPVTGKKTSNAPTPQVVPATVPSTTNLSAAGTPNIRNKSATPLTAGLSPKSTIRSNSNTALASAKTPSPMTVSIPQPGNSSVFKKEEEYLSKLQLRKEEIRFRQKQRLDILSSSPVDLFLTTVADCLGINDEEIELINKIPETTADNINNTGKKKLTKAAQKLRDKEILNVSIQVGEKDKLIMSSKAPDKVMDYSISAMSLAAVFKNLSSTGSLNNIALSGSNATTSKDIGNIYSHTGGVKRKFDEVEISPNSNGSPSASIMSESKKIKIDSPEDMFVTHSSEAAKGTNNSSLMDSGKEGSCKSMAGSATEVNDTSIWDWNFWTSIE
  
Inhibitor
Name:
BDBM50457392
Synonyms:
CHEMBL4207615
Type:
Small organic molecule
Emp. Form.:
C10H8Cl2N4OS
Mol. Mass.:
303.168
SMILES:
Clc1ccc(NC(=S)NNC(=O)CC#N)cc1Cl
Structure:
Search PDB for entries with ligand similarity: