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Target
L-ornithine N(5)-monooxygenase
Ligand
BDBM50071058
Substrate
n/a
Meas. Tech.
ChEMBL_1759484 (CHEMBL4194492)
Kd
1400±n/a nM
Citation
 Liu, N; Tu, J; Dong, G; Wang, Y; Sheng, C Emerging New Targets for the Treatment of Resistant Fungal Infections. J Med Chem 61:5484-5511 (2018) [PubMed]  Article 
Target
Name:
L-ornithine N(5)-monooxygenase
Synonyms:
Flavin-Dependent Monooxygenase Siderophore A (SidA) | SIDA_ASPFU | sidA
Type:
Protein
Mol. Mass.:
56889.65
Organism:
Aspergillus fumigatus (Fungus)
Description:
E9QYP0
Residue:
501
Sequence:
MESVERKSESSYLGMRNMQPEQRLSLDPPRLRSTPQDELHDLLCVGFGPASLAIAIALHDALDPRLNKSASNIHAQPKICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRSSFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSSSVVDFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDKSKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIMRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEEIYNDMYLQRVKNPDETQWQHRILPERKITRVEHHGPQSRMRIHLKSSKPESEGAANDVKETLEVDALMVATGYNRNAHERLLSKVQHLRPTGQDQWKPHRDYRVEMDPSKVSSEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGEQLERAAVQGHQLRAML
  
Inhibitor
Name:
BDBM50071058
Synonyms:
(2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid | CELASTROL | CHEMBL301982 | cid_4274774
Type:
Small organic molecule
Emp. Form.:
C29H38O4
Mol. Mass.:
450.6096
SMILES:
C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17|
Structure:
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