Reaction Details Report a problem with these data
Target
Glutamyl aminopeptidase
Ligand
BDBM50457482
Substrate
n/a
Meas. Tech.
ChEMBL_1759798 (CHEMBL4194806)
Ki
13±n/a nM
Citation
 Amin, SA; Adhikari, N; Jha, T Design of Aminopeptidase N Inhibitors as Anti-cancer Agents. J Med Chem 61:6468-6490 (2018) [PubMed]  Article 
Target
Name:
Glutamyl aminopeptidase
Synonyms:
AMPE_HUMAN | AP-A | Aminopeptidase A | CD_antigen=CD249 | Differentiation antigen gp160 | EAP | ENPEP | Glutamyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
109226.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_32829
Residue:
957
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
  
Inhibitor
Name:
BDBM50457482
Synonyms:
CHEMBL4217064
Type:
Small organic molecule
Emp. Form.:
C16H27N3O8S
Mol. Mass.:
421.466
SMILES:
CC[C@H](C)[C@H](NC(=O)C(S)C(N)CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Structure:
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