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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50457575
Substrate
n/a
Meas. Tech.
ChEMBL_1760115 (CHEMBL4195123)
Ki
0.700000±n/a nM
Citation
 Pa?czyk, K; Pytka, K; Jakubczyk, M; Rapacz, A; Sa?at, K; Furga?a, A; Siwek, A; G?uch-Lutwin, M; Grybo?, A; S?oczy?ska, K; P?kala, E; ?mudzki, P; Bucki, A; Ko?aczkowski, M; ?elaszczyk, D; Marona, H; Waszkielewicz, AM Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system. Bioorg Med Chem Lett 28:2039-2049 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50457575
Synonyms:
CHEMBL3979261
Type:
Small organic molecule
Emp. Form.:
C22H31ClN2O2
Mol. Mass.:
390.947
SMILES:
Cl.COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1
Structure:
Search PDB for entries with ligand similarity: