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Target
Interleukin-1 receptor type 1
Ligand
BDBM50457655
Substrate
n/a
Meas. Tech.
ChEMBL_1760481 (CHEMBL4195489)
IC50
720±n/a nM
Citation
 Zhang, L; Shi, L; Soars, SM; Kamps, J; Yin, H Discovery of Novel Small-Molecule Inhibitors of NF-?B Signaling with Antiinflammatory and Anticancer Properties. J Med Chem 61:5881-5899 (2018) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor type 1
Synonyms:
CD121 antigen-like family member A | CD_antigen=CD121a | IL-1R-1 | IL-1R-alpha | IL-1RT-1 | IL-1RT1 | IL1R | IL1R1 | IL1R1_HUMAN | IL1RA | IL1RT1 | Interleukin-1 receptor alpha | Interleukin-1 receptor type 1 | Interleukin-1 receptor type 1, membrane form | Interleukin-1 receptor type 1, soluble form | Interleukin-1 receptor type I | mIL-1R1 | mIL-1RI | p80 | sIL-1R1 | sIL-1RI
Type:
PROTEIN
Mol. Mass.:
65411.77
Organism:
Homo sapiens
Description:
ChEMBL_198
Residue:
569
Sequence:
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
  
Inhibitor
Name:
BDBM50457655
Synonyms:
CHEMBL4213787
Type:
Small organic molecule
Emp. Form.:
C16H10Cl2N4O2S
Mol. Mass.:
393.247
SMILES:
Clc1ccc(-c2nc(cs2)C(=O)NNC(=O)c2ccccn2)c(Cl)c1
Structure:
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