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Target
Dihydrofolate reductase
Ligand
BDBM50022239
Substrate
n/a
Meas. Tech.
ChEBML_54893
IC50
1600±n/a nM
Citation
 DeGraw, JI; Colwell, WT; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin. J Med Chem 29:1786-9 (1986) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50022239
Synonyms:
2-[4-(7,9-Diamino-1-oxo-1,2,3,3a,4,5-hexahydro-6,8,9b-triaza-cyclopenta[a]naphthalen-2-yl)-benzoylamino]-pentanedioic acid | CHEMBL299863
Type:
Small organic molecule
Emp. Form.:
C22H24N6O6
Mol. Mass.:
468.4626
SMILES:
Nc1nc(N)c2N3C(CC(C3=O)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)CCc2n1
Structure:
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