Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50022273
Substrate
n/a
Meas. Tech.
ChEBML_31911
IC50
210±n/a nM
Citation
 Cerelli, MJ; Curtis, DL; Dunn, JP; Nelson, PH; Peak, TM; Waterbury, LD Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids. J Med Chem 29:2347-51 (1986) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50022273
Synonyms:
2-(4-Hydroxy-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yl)-propionic acid | CHEMBL77692
Type:
Small organic molecule
Emp. Form.:
C18H16O4
Mol. Mass.:
296.3172
SMILES:
CC(C(O)=O)c1cc(O)c2c(CCc3ccccc3C2=O)c1
Structure:
Search PDB for entries with ligand similarity: