Reaction Details
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Group 10 secretory phospholipase A2
Ligand
BDBM50458617
Substrate
n/a
Meas. Tech.
ChEMBL_1764267 (CHEMBL4199514)
IC50
42±n/a nM
Citation
Giordanetto, F; Knerr, L; Nordberg, P; Pettersen, D; Selmi, N; Beisel, HG; de la Motte, H; Månsson, Å; Dahlström, M; Broddefalk, J; Saarinen, G; Klingegård, F; Hurt-Camejo, E; Rosengren, B; Wikström, J; Wågberg, M; Brengdahl, J; Rohman, M; Sandmark, J; Åkerud, T; Roth, RG; Jansen, F; Ahlqvist, M Design of Selective sPLA ACS Med Chem Lett 9:600-605 (2018) [PubMed] Article More Info.:
Target
Name:
Group 10 secretory phospholipase A2
Synonyms:
Group X secretory phospholipase A2 | PA2GX_HUMAN | PLA2G10
Type:
PROTEIN
Mol. Mass.:
18153.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442449
Residue:
165
Sequence:
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
Inhibitor
Name:
BDBM50458617
Synonyms:
CHEMBL4215835
Type:
Small organic molecule
Emp. Form.:
C19H16F3N3O4
Mol. Mass.:
407.3432
SMILES:
CC(CC(O)=O)c1cccc(n1)-n1c(cc2ccc(OC(F)(F)F)cc12)C(N)=O
Structure:
