Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50392861
Substrate
n/a
Meas. Tech.
ChEMBL_1764695 (CHEMBL4199942)
EC50
160±n/a nM
Citation
 Brown, SP; Dransfield, P; Vimolratana, M; Zhu, L; Luo, J; Zhang, J; Jiao, X; Pattaropong, V; Wong, S; Zhuang, R; Swaminath, G; Houze, JB; Lin, DC Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett 9:757-760 (2018) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50392861
Synonyms:
CHEMBL2152070
Type:
Small organic molecule
Emp. Form.:
C33H35FO4
Mol. Mass.:
514.627
SMILES:
COc1ccc(F)c(c1)-c1ccc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cc1C1=CCCC1(C)C |r,t:35|
Structure:
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